Self-assembly of Gold Nanoparticles by Hybridization of Two Complementary DNAs
Gold nanoparticles were synthesized by reducing HAuCl4 with trisodium citrate. These gold nanoparticles could react with disulfide group modified DNAs well. The DNAs modified gold nanoparticles assembled into regular array according to the hybridization of two complementary DNAs linked on gold nanoparticles individually. This reaction caused the color of gold nanoparticle solution changed from red to blue. Thus, this phenomenon showed the potential of DNAs modified gold nanoparticles to be applied in biosensing or as DNA probes for diagnosis.